Journal article
Characterising seizure development, behavioural comorbidities and neuroinflammation in a self-sustained electrical status epilepticus model of mesial temporal lobe epilepsy in C57BL/6J mice
P Thergarajan, MR Hudson, I Carmichael, J Clasadonte, S Dedeurwaerdere, TJ O'Brien, NC Jones, I Ali
Neurobiology of Disease | Published : 2022
Abstract
Objective: Status epilepticus (SE) models in rodents are commonly used to research mesial temporal lobe epilepsy (mTLE) in translational epilepsy research. However, due to differences in susceptibility of mice strains to chemoconvulsants, developing this model in mice is challenging. Mice offer experimental advantages; in particular, the ability to use transgenic strains could provide novel insights about neurobiological mechanisms or ease of genetic modification to test potential therapeutic targets. This study aimed to characterise the neuroinflammation, epileptic seizures and behavioural comorbidities after self-sustained Electrical Status Epilepticus (SSSE) in C57BL/6J mice. Methods: SSS..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The work was supported by NHMRC Investigator Grant (APP1176426) and NHMRC Program Grant (##APP1091593) .